H2N2V1, 1968, Analysis, bibRecord, 000194

The influenza virus: Antigenic composition and immune response.

Identifieur interne : 000194 ( 1968/Analysis ); précédent : 000193; suivant : 000195

The influenza virus: Antigenic composition and immune response.

Auteurs : G. C. Schild

Source :

Postgraduate Medical Journal [ 0032-5473 ] ; 1979-02.

RBID : ISTEX:D9DDF3AEFBC2BCE31382D86716696E25F1CF9288

English descriptors

Teeft :
- Academic press, Antibody, Antibody formation, Antibody molecules, Antibody production, Antibody response, Antibody responses, Antigen, Antigenic, Antigenic composition, Antigenic determinants, Antigenic differences, Antigenic drift, Antigenic variability, Antigenic variants, Antigenic variation, Antigenically, Asian virus, Avian, Avian origin, Avian sources, Causative virus, Considerable antigenic, Cytotoxic, Cytotoxic response, Determinant, Dowdle, Experimental medicine, Gene segments, General virology, Genetic recombination, Genome, H1nj, H1nj virus, H1nj viruses, Haemagglutinin, High degree, Hong kong, Hong kong virus, Human influenza, Human sera, Immune, Immune goat serum, Immune response, Immunization, Immunological, Influenza, Influenza antigens, Influenza cells, Influenza infection, Influenza vaccines, Influenza virus, Influenza virus genome, Influenza virus haemagglutinin, Influenza virus particle, Influenza virus particles, Influenza viruses, Internal protein, Kilbourne, Laver, Many years, Matrix, Matrix protein, Military recruits, National academy, Neuraminidase, Original antigenic, Pereira, Polypeptide, Prevalent influenza, Progressive antigenic, Protective effect, Protein components, Ribonucleoprotein antigen, Schild, Single subtype, Surface antigens, Target cells, Term antigenic, Thymus dependence, Unknown mechanism, Vaccine, Vaccine virus, Virelizier, Virology, Virus, Virus infectivity, Virus particle, Virus particles, Virus strains, World health organization, Young persons.

Abstract

The architecture and chemical composition of the influenza virus particle is described with particular reference to the protein constituents and their genetic control. The dominant role in infection of the surface proteins - haemagglutinins and neuraminidases - acting as antigens and undergoing variation in time known as antigenic drift and shift is explained. The immuno-diffusion technique has illuminated the interrelationships of the haemagglutinins of influenza A viruses recovered over long periods of time. The H0 and H1 haemagglutinins are now regarded as a single sub-type with H2 and H3 representing the haemagglutinins of the 1957 and 1968 sub-types. Animal influenza viruses of pigs, horses and birds are described. A relation to human influenza strains has been shown to exist in certain instances as is the capacity of some human strains to pass to the animal kingdom.

Url:

DOI: 10.1136/pgmj.55.640.87

Affiliations:

Links to Exploration step

ISTEX:D9DDF3AEFBC2BCE31382D86716696E25F1CF9288

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The influenza virus: Antigenic composition and immune response.

The influenza virus: Antigenic composition and immune response.

Source :

English descriptors

Abstract

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